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Farran, Arij B.
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Chemistry 4400 Massachusetts Avenue NW Washington, DC 20016-8014 United StatesSpotlight: Kelsey Kirsch
Kelsey Kirsch (Senior-Biochemistry '25), recently published as a first author in the journal Dalton Transactions. Her work was titled "Direct O2 mediated oxidation of a Ni(II)-N3O structural model for the active site of nickel acireductone dioxygenase (Ni-ARD): Characterization, biomimetic reactivity, and enzymatic implications." Kelsey is a student in the lab of Dr. Santiago Toledo, where research investigates the involvement of metalloenzymes in disease. Kelsey's work focuses on studying the reactivity and mechanism of a known "moonlighting" function of the metalloenzyme acireductone dioxygenase (ARD).
This alternative reactivity displayed by ARD has been linked to the development of cancer. Kelsey's work is the first functional and structural biomimetic model of ARD. Additionally, this work highlights the first example of a nickel coordination compound that is capable of activating O2 directly. This reactivity has broad implications on how other similar enzymes might display aberrant behavior in nature. Kelsey started working in the Toledo lab at the beginning of her sophomore year. Kelsey was the lead person in this project. She is also a supplemental instructor for General Chemistry I and is a member of the Department's recruitment and retention committee. Kelsey intends to enter into a PhD program in Chemistry in the Fall of 2025.